specified its critical role in immunity, It's not at all surprising that surplus MIF expression has become associated with exaggerated inflammation and immunopathology. On top of that, MIF demonstrates nicely-documented proliferative properties. MIF is secreted by a lot of differing types of cells and interacts with many receptors, which helps to clarify The range of biological capabilities. Receptors that interact that bind MIF consist of CD74, and chemokine receptors CXCR2 and CXCR4 (7–fifteen).
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(CLP). An experimental product of an infection that mimics human peritonitis. following laparotomy, the caecum is ligated distal to the ileocecal valve and punctured by using a calibrated needle to provide leakage of faeces to the peritoneal cavity.
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Structural options of MIF make this cytokine well suited for modest-molecule antagonism in rheumatic conditions.
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